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The CyberKnife® Robotic Radiosurgery System is a non-invasive alternative to surgery for the treatment of both cancerous and non-cancerous tumors anywhere in the body.

The CyberKnife is a frameless robotic radiosurgery system invented by John R. Adler, a Stanford University Professor of Neurosurgery and Radiation Oncology, and Peter and Russell Schonberg of Schonberg Research Corporation. The two main elements of the CyberKnife are the radiation produced from a small linear particle accelerator and a robotic arm which allows the energy to be directed at any part of the body from any direction.

The CyberKnife system is a method of delivering radiotherapy, with the intention of targeting treatment more accurately than standard radiotherapy. It is not widely available, although the number of centres offering the treatment around the world has grown in recent years to over 150, particularly centered in North America, East Asia and Europe – the first UK CyberKnife was opened at The Harley Street Clinic in February 2009.

The CyberKnife system is sold by the company Accuray, located in Sunnyvale, California. The CyberKnife system is used for treating benign tumors, malignant tumors and other medical conditions.